Instrumentation

Automate Cellular Proteomics

Automate your entire workflow with the IsoLight system. The IsoLight’s innovative and impactful end-to-end workflow covers a wide range of applications, from early optimization to applying key, correlative insights and visualizations.

The IsoLight System: A Breakthrough in Multiplexed Proteomics

Traditional Workflow

Multiple Instruments Needed

Multiple Manual Workflow Steps

Automate Your Entire Workflow with One System

The IsoLight System

The New Standard in Functional Biomarkers

01 Sample Prep

Following IsoPlexis’ sample prep protocols, samples are loaded onto the IsoCode Chip in one pipette action.

02 Load Chips

Up to eight IsoCode Chips with a throughput up to 8k single cells per run can be loaded.

03 Automated Workflow

Automated cellular imaging, proteomic imaging and ELISA workflow for hands-off generation of single-cell functional data.

04 Data Visualization

Automated on-site analysis and advanced, functional, single cell mapping with IsoSpeak Software.

Unique Visualization Options

A unique set of visualizations shows the impact of polyfunctionality and what it’s made up of, including:

  • – 3D t-SNE cell mapping
  • – Polyfunctional Strength Index (PSI™)
  • – Single-cell polyfunctional heat map
  • – Percentage of polyfunctional cells
  • – Individual cytokine intensities secreted by single cells
  • – Polyfunctional Activity Topography (PAT) PCA
  • – Toggle which data subsets are visualized and make customizations in the intuitive dashboard

Following IsoPlexis’ sample prep protocols, samples are loaded onto the IsoCode Chip in one pipette action.

Applications

Single-Cell
Adaptive Immune

A fully automated solution for single-cell functional phenotyping of immune cells.

Single-Cell
Innate Immune

Single-cell functional phenotyping for innate & myeloid cell types, automated on the IsoLight System.

Single-Cell
Inflammation

Reveal the functional sources of inflammation from rare polyfunctional subsets of cells in an automated manner.

Single-Cell
Intracellular Proteome

Measure cellular protein to protein interactions and adaptive resistance pathways.

CodePlex
Secretome

Run an entire multiplexed ELISA workflow in a completely automated and hands-off manner.

CodePlex
Intracellular Proteome

Run an entire multiplexed ELISA workflow in a completely automated and hands-off manner.

Cytokine
Storm Package

Harnessing the power of functional proteomics with the IsoLight™.

Solutions & Kits

The Single-Cell Secretome solution enables the discovery of better biomarkers and accelerated development through functional immune landscaping of each immune cell, allowing for complete single-cell functional characterization. Detect rare subsets of “super cells” to reveal functional biological drivers of persistence, potency, durability and more.

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The Single-Cell Intracellular Proteome for intracellular signaling omics provides functional characterization of the signaling networks and resistance pathways of cancer cells for the development of improved treatments to combat therapeutic resistance.

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The Single-Cell Metabolome solution measures functional energy states and adaptive resistance pathways.

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With high-plex walk-away immunoassays, unleash super-powered and super-automated multiplexed proteomics in very low sample volumes to access insights right away. With a faster and more streamlined approach to generating multiplexed bulk cytokine data via a fully automated workflow, CodePlex offers a modular solution to bulk cytokine data analysis and minimizes variability from user input.

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IsoPlexis’ CodePlex solution is helping researchers by providing a faster and more streamlined approach to generating intracellular proteomics data via a fully automated end-to-end workflow. It does this by offering a modular solution to bulk phosphoprotein data analysis and minimizing variability from user input.

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IsoPlexis’ CodePlex solution is uniquely capturing key measures of metabolomics in an automated manner.

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