Microfluidic Chips

∙ Linear Channels

∙ Bifurcating Channels

∙ Microvascular Networks

∙ Idealized Networks

Use Linear Channels for studying cell/particle adhesion and cell-cell or cell-particle interactions at the micro-circulation scale. Use as a substitute for parallel plate flow chambers for >90% savings in consumables.

Linear Channels Design Library

Three channels per chip of various widths to allow you to study shear effects based on channel size and flow rates.

Standard Width Options (W1 / W2 / W3):

∙ 100 μm / 100 μm / 100 μm

∙ 250 μm / 250 μm / 250 μm

∙ 500 μm / 500 μm / 500 μm

∙ 100 μm / 250 μm / 500 μm

Custom designs/sizes also available.

Use symmetric and asymmetric bifurcations to study cell/particle adhesion and cell-cell or cell-particle interactions at bifurcations and to study the effect of the bifurcation angle and asymmetry on adhesion. Compare adhesion in linear sections and bifurcations simultaneously.

Bifurcating Channels Design Library

With various options of symmetric and asymmetric bifurcating angles and parent/daughter channel widths you can likely find a set of designs to provide you the best models for your research.

Standard Symmetric Bifurcation Angle (θB/θC) Options:

∙ 15° + 15°

∙ 30° + 30°

∙ 45° + 45°

∙ 60° + 60°

Custom designs/sizes also available.

Use Microvascular Networks to replicate in vivo cell/particle adhesion and cell-cell or cell-particle interactions in an in vitro setting. Investigate effects of flow and morphology for drug delivery, drug discovery and cellular behavior. Obtain shear-adhesion maps and bifurcation vs. branch adhesion in single experiment.

Microvascular Network Design Library

Network 001, 100μm depth

SMN1-C001 (104001)

Network 002, 100μm depth

SMN1-D001 (104002)

Network 003, 100μm depth (M#55)

SMN1-C002 (104003)

Network 004, 100μm depth (M#55)

SMN1-C003 (104004)

Network 005, 100μm depth (M#55)

SMN1-C004 (104005)

Network 006, 100μm depth (M#55)

SMN1-C005 (104006)

Network 007, 100μm depth (M#55)

SMN1-C006 (104007)

Network 008, 100μm depth (M#55)

SMN1-C007 (104008)

Network 009, 100μm depth (M#56)

SMN1-D002 (104009)

Network 010, 100μm depth (M#56)

SMN1-D003 (104010)

Network 011, 100μm depth (M#56)

SMN1-D004 (104011)

Network 012, 100μm depth (M#56)

SMN1-D005 (104012)

Network 013, 100μm depth (M#56)

SMN1-D006 (104013)

Network 014, 100μm depth (M#56)

SMN1-D007 (104014)

Use network co-culture assays to replicate the in vivo physiological and morphological conditions in addition to desired cellular makeup.

Co-Culture Network Design Library

By incorporating natural tissue regions within the network topology, the co-culture networks allow study of cell and drug behavior at and across the interfaces. The co-culture network constructs are available with several options for channel size, tissue region scaffolding, and barrier design. We can help you select the right parameters for your needs and can also construct custom designs if needed.

3 um Height Barrier: 10um Dia-50um Separation, 100 um Depth

SMN2-C001 (105001)

3 um Height Barrier: 10um Dia-50um Separation, 100 um Depth

SMN2-D001 (105002)

Multi-chambered chips for studying the effect of high and low perfusion

Use these chips for studies of tumor microenvironment based on differential flow gradients and metastasis.

SMN3-C002 (106009)

SMN3-D002 (106010)

Tandem-co-culture chips used for real time visualization and quantitation of tumor metastasis

Tandem chips are designed with synthetic tumor networks comprising primary and secondary tumor sites. This chip has been used to develop a 3D vascularized model for monitoring the invasive growth patterns and metastatic potential of tumors, thereby mimicking both the in vivo microenvironment of solid tumors, cancer invasion and metastasis. This model can be used to investigate tumor-endothelial cell interactions using a combination of real-time imaging techniques and screening of targeted therapeutics that may reduce the metastatic potential of tumors.

SMN3-JN1-100 (106013)

Use idealized co-culture assays to mimic the cellular make up in vivo. Investigate cell-cell interactions and perfusion vs. diffusion based affects. Analyze the experiments in real-time for all the cell populations.

Co-Culture Design Library

Intended to mimic the formation of and transport across tight and gap junctions such as the blood-brain barrier and other endothelial/tissue interfaces, the idealized co-culture constructs are available with several options for channel size, tissue chamber size and scaffolding, and barrier design. We can help you select the right parameters for your needs and can also construct custom designs if needed. Please contact us for details.

Slit Barrier or Pillar Barrier Options

Slit Barriers:

These device utilizes slits and gaps to form the barrier region between the outer channel and inner chamber.

Standard design parameters available are:

∙ Outer Channel Width (OC): 100 μm or 200 μm

∙ Travel Width (T): 50 μm or 100 μm

∙ Slit Spacing (SS): 50 μm or 100 μm

∙ Slit Width (WS): Variable

Radial IMN2/IMN3 Slit Options

IMN2 Slit/Pillar

IMN2/3 Slit

IMN2 Pillar

IMN2/3 Slit Detail

IMN2 Pillar Detail

Pillar Barrier Options

These devices utilize pillars to form the barrier region between the outer channel and inner chamber.

Standard design parameters available are:

∙ Outer Channel Width (OC): 100 μm or 200 μm

∙ Travel Width (T): 50 μm or 100 μm

∙ Pillar Spacing (Gap) (SP): 8μm or 3μm

∙ Pillar Diameter (DP): Variable

∙ Pore sizes available 3μm or 8μm

Radial IMN3 Pillar Option

IMN2 Slit/Pillar

IMN2/3 Slit

IMN2 Pillar

Linear IMN2 chips